Chemoselective Deprotection of Triethylsilyl Ethers
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چکیده
منابع مشابه
Chemoselective deprotection of triethylsilyl ethers.
An efficient and selective method was developed for the deprotection of triethylsilyl (TES) ethers using formic acid in methanol (5-10%) or in methylene chloride 2-5%) with excellent yields. TES ethers are selectively deprotected to the corresponding alcohols in high yields using formic acid in methanol under mild reaction conditions. Other hydroxyl protecting groups like t-butyldimethylsilyl (...
متن کاملThe chemoselective and efficient deprotection of silyl ethers using trimethylsilyl bromide.
An efficient and chemoselective cleavage of silyl ethers (primary, secondary and aromatic) by using catalytic quantities of trimethylsilyl bromide (TMSBr) in methanol is reported. A wide range of alkyl silyl ethers such as TBS, TIPS, and TBDPS can be chemoselectively cleaved in high yield in the presence of aryl silyl ethers. The deprotection of silyl esters was also achieved employing catalyti...
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In multi-step organic syntheses, the protection and deprotection of tetrahydropyranyl (THP) ethers is one of the most frequently used methods. Over the years, different methods have been used from various catalytic systems for the protection of hydroxyl groups as THP ethers and their deprotection. Herein we have reported that various alcohols and phenols have been efficiently converted to the c...
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Structurally different trimethyl silyl ethers are oxidized with Bu4/NIO4 in the presence of AlCl3 and BF3 as catalysts in CH3CN and CHCl3 under reflux conditions. The corresponding carbonyl compounds are isolated in good yields.
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An efficient method for the cleavage of the p-methoxybenzyl protecting group of several alcohols in the presence of 0.5 equiv of trifluoromethanesulfonic acid and 1,3-dimethoxybenzene in dichloromethane at room temperature is described. 2011 Elsevier Ltd. All rights reserved. O OAc Me HO PMBO O-allyl 1 O AcO AcO NPhth AcO O NH CCl3 2 O OAc Me O O AcO AcO AcO
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ژورنال
عنوان ژورنال: Nucleosides, Nucleotides and Nucleic Acids
سال: 2009
ISSN: 1525-7770,1532-2335
DOI: 10.1080/15257770903362172